While Trinity College was founded by Queen Elizabeth I in 1592, it was not until the 18th centuary that a formal Medical School and curriculum were established. The first Professor of Materia Medica and Pharmacy was appointed in 1749. The parctice of a Senior Physician teaching Materia Medica/Therapeutics was maintained until the 1950's. Following an international review, a more science-baced preclinical Pharmacology Department was establised in the 1960's under Dr G.W. Pennington when he was appointed lecturer in charge of the Department. A clinical Senior lecturer (part-time) contributed in the clinical years. With support from the Wellcome Foundation, research laboratories were established. With the retirement of the Professor of Pharmacology, C.M. Wilson, in the early 1980's, the University decided to restructure the replacement appointment with one in Clinical Pharmacology. The Department took on more clinical responsibilities and was renamed and the Chair in Pharmacology and Therapeutics was established in 1984. A number of distinct areas evolved over the years, and currently include: Cardiovascular Pharmacology (hypertension, vascular function, lipids and antioxidants), Neuropharmacology, Clinical Pharmacology (Drug metabolism, formulary management, pharmacoeconomics and pharmacoepidemiology).



Investigators


Professor Michael Rowan

Prof Rowan has over 20 years experience with highly sophisticated electrophysiological techniques, including long-term field potential recording in in vivo preparations. Over the last several years he has co-directed, with Professor Roger Anwyl (Physiology Department, Trinity College Dublin), a very successful group investigating the mechanisms of regulation of synaptic plasticity in the hippocampus. Major recent discoveries include the role of glutamate receptors and environmental factors, including stress, in the induction and maintenance of long-term potentiation. He has extensive experience in managing the research of the group, which at the moment consists of 10 research staff and which will continue to have the necessary space and related infrastructural requirements provided. Trinity College has extensive financial, research and innovation services to ensure more than adequate support for the project. Professor Rowan has collaborated on and helped co-ordinate four highly successful EU funded projects in the last 10 years.



Dr William Cullen

William Cullen is an Experimental Officer in the Department of Pharmacology and Therapeutics. He has had over 20 years experience in this research area and will provide experimental support and training for the workpackage.



Dr Igor Klyubin

Igor Klyubin is a postdoctoral researcher who has over 8 years experience with electrophysiology techniques. He will be largely responsible for the electrophysiology experiments in the CA1 area of anaesthetised rats.



Dr Laura Spowart-Manning

Laura Spowart-Manning hhas over 5 years experience with in vivo electrophysiology and related behavioural techniques.